Interesante articulo que revela como hay mas genes en alzheimer y como estos promueven en cel.

De microglis la formacion de placas amiloides

A novel approach to treating Alzheimer’s disease (AD) is suggested by research headed by Rudolph Tanzi, Ph.D., a professor of neurology at Harvard Medical School, and reported in the journal Neuron. For a long time, the APOE-e4 gene variant remained the only known genetic risk factor for late-onset Alzheimer’s. Then recently, genomewide association studies performed on thousands of individuals led to the identification of more genes implicated in AD, one of which is called CD33.

Now Tanzi and his colleagues have found, in brain tissue samples taken from deceased individuals who had AD, that higher levels of CD33 in microglia—immune cells that clean up debris in the brain—were associated with an increased number of beta-amyloid plaques, a hallmark of the illness. Thus it looked as if the gene prevented beta-amyloid clearance in the brain. Indeed, when the researchers deactivated the CD33 gene in mice, they found that the deactivation enhanced the ability of microglia to clear up beta-amyloid molecules.

“This is the first time that we have direct evidence of a gene, CD33, that directly controls beta-amyloid clearance by microglia,” Tanzi said in a press statement. “Our findings raise the exciting possibility that the inability of microglia to degrade beta-amyloid in Alzheimer’s disease could be reversed therapeutically by inhibition of CD33 activity.”

To read more about strategies that might be able to avert AD, see Psychiatric News here and here. Information about diagnosis and treatment of AD can be found in American Psychiatric Publishing’s

También puede gustarte...

1 Comentario

  1. 2 percentage points from the first three months. Websites for societal bookmarks were initially intended for an online resource which practically anyone could exploit that is until it absolutely was discovered that it presents an excellent opportunity for one-way connection building. Using the same you can enjoy, free online RV site builder option, free domain name facility, free fantastico, free private name servers and many other things, which will surely make your online journey easier and you will love to use the same forever. Even so, chiropractic physicians at the hub of a person’s damage or overall health can immediate treatment that needs to be carried out by the suitable specialist. What exactly is creating of social bookmarks? Social bookmarking for being an effective and viable SEO strategy revolves around storing and organizing bookmarks in fairly much the same way as anyone add sites for a favorites except that in such a case, Wholesale Jerseys,Wholesale NFL Jerseys China, the websites that bookmarked can end up accessed by anybody online. Do not expect to earn huge profits from a start up.It is enjoyable for some people in seeking the answer as various maze of question with an eagerness ego on solving it.”The serial number on the motherboard did not match with the serial number on the exterior of the smartphone,” said the test report issued by the authorized Apple service shop.Cheap NFL Jerseys China Wholesale. 14 in Copenhagen.Cote d’Ivoire started its claims over the territory after Ghana discovered oil in commercial quantities in 2007 and 2009.So that they won’t face any difficulties in the future, you will teach them and give them a book about mathematics so that they will be armed and ready for the future might lead. When looking at points of the shopping list, check out which you have the respective discount also.Visit my site??

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *